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p-β-catenin Antibody (24E1): sc-57534

 |  Datasheet

(Based on data analysis)

  • p-β-catenin Antibody (24E1) is a mouse monoclonal IgG1 provided at 50 µg/ 0.5 ml
  • raised against a synthetic phosphopeptide of β-catenin of human origin
  • recommended for detection of Tyr 86 phosphorylated β-catenin of mouse, rat and human origin by WB and IP
 

See additional Catenin Antibodies including Catenin, alpha E-catenin, alpha N-catenin, alpha T-catenin , beta-catenin, delta-catenin and gamma-catenin.

Also see beta-catenin Inhibitors for functional analysis of cellular responses to beta-catenin.


Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
p-β-catenin Antibody (24E1) sc-57534 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
β-catenin siRNA (h) sc-29209 10 µM $258
β-catenin siRNA (m) sc-29210 10 µM $258
β-catenin (h)-PR sc-29209-PR 10 µM, 20 µl $23
β-catenin (m)-PR sc-29210-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
β-catenin shRNA Plasmid (h) sc-29209-SH 20 µg $520
β-catenin shRNA Plasmid (m) sc-29210-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
β-catenin shRNA (h) Lentiviral Particles sc-29209-V 200 µl $625
β-catenin shRNA (m) Lentiviral Particles sc-29210-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human GORASP2 26003 2q31.1 NM_015530 Q9H8Y8
 608693
Mouse Ctnnb1 12387 9 F4 Q02248
 N/A
 

The catenins, å, ∫ and ©, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. ∫-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. ∫-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3∫, result in accumulation of the ∫-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of ∫-catenin signaling that directly binds a phosphorylated Ser-Pro motif next to the APC-binding site in ∫-catenin, inhibiting the interaction with APC and increasing ∫-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of ∫-catenin in tumors such as breast cancer.
p-β-catenin Antibody (24E1) Data
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sc-57534
p-β-catenin (24E1): sc-57534. Western blot analysis of β-catenin phosphorylation in non-stimulated (A), and pervanadate stimulated (B) SW480 whole cell lysates.
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