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Syk Antibody (LR): sc-573

 |  Datasheet

(Based on data analysis)

  • Syk Antibody (LR) is a rabbit polyclonal IgG provided at 200 µg/ml
  • epitope mapping within the “linker” region of Syk of human origin
  • recommended for detection of Syk of mouse, rat and human origin by WB, IP, IF, FCM and ELISA
  • agarose conjugate for IP studies, sc-573 AC, 500 µg/0.25 ml agarose
  • phycoerythrin conjugate for intracellular FCM, sc-573 PE, 100 tests
  • See 39 citations for Syk Antibody (LR)
 

See additional Syk Antibodies.

Also see Syk Inhibitors for functional analysis of cellular responses to Syk.


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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Syk Antibody (LR) sc-573 200 µg/ml $279
Syk Antibody (LR) AC sc-573 AC 500 µg/ml, 25% ag $366
Syk Antibody (LR) PE sc-573 PE 100 tests in 2 ml $303
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Syk siRNA (h) sc-29501 10 µM $258
Syk siRNA (m2) sc-44328 10 µM $258
Syk (h)-PR sc-29501-PR 10 µM, 20 µl $23
Syk (m2)-PR sc-44328-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Syk shRNA Plasmid (h) sc-29501-SH 20 µg $520
Syk shRNA Plasmid (m2) sc-44328-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Syk shRNA (h) Lentiviral Particles sc-29501-V 200 µl $625
Syk shRNA (m2) Lentiviral Particles sc-44328-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Syk (h): 293 Lysate sc-111124 100 µg/200 µl $205
BJAB Whole Cell Lysate sc-2207 500 µg/200 µl $104
NAMALWA Cell Lysate sc-2234 500 µg/200 µl $104
RAW 264.7 Whole Cell Lysate sc-2211 500 µg/200 µl $104
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
Syk (h): 293 Lysate sc-111124 100 µg/200 µl $205
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SYK 6850 9q22.2 NM_003177 P43405
 600085
Mouse Syk 20963 13 A5 P48025
 N/A
 

Syk (spleen tyrosine kinase) is a 635 amino acid protein that contains one protein kinase domain and two SH2 domains. One of several members of the protein kinase superfamily, Syk functions as a positive effector of B cell antigen receptor (CD79)-stimulated responses, coupling CD79 with the movement of one calcium ion through one of two phospho-regulated pathways. Specifically, calcium ions travel through either a phosphoinositide 3-kinase (PI 3-kinase)-dependent pathway when Syk is not phosphorylated, or through a phospholipase C (PLC) ©-dependent pathway when human Syk is phohsphorylated on Tyr 348 and Tyr 352. Via its ability to influence CD79 activity and to control the movement of calicum through the cell, Syk plays an important role in a variety of cellular responses, including differentiation, phagocytosis, proliferation and B cell development. Syk expression is upregulated in T cell lymphoma, suggesting a possible role for Syk in tumorigenesis. Two isoforms of Syk, designated short and long, exist due to alternative splicing events.

Syk Antibody (LR) Product Citations
See how others have used Syk Antibody (LR) and or Syk Antibody (LR) conjugates.


39 total citations
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Syk Antibody (LR) Data
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sc-573
Syk (LR): sc-573. Western blot analysis of Syk expression in BJAB (A) and Ramos (B) whole cell lysates.
sc-573
Syk (LR) PE: sc-573 PE. Intracellular FCM analysis of fixed and permeabilized BJAB cells. Black line histogram represents the isotype control, normal rabbit IgG: sc-3871.
sc-573
Syk (LR): sc-573. Western blot analysis of Syk expression in non-transfected: sc-110760 (A) and human Syk transfected: sc-111124 (B) 293 whole cell lysates.
sc-573
Syk (LR): sc-573. Western blot analysis of Syk expression in non-transfected: sc-110760 (A) and human Syk transfected: sc-111124 (B) 293 whole cell lysates.
sc-573
Syk (LR): sc-573. Western blot analysis of Syk expression in non-transfected: sc-110760 (A) and human Syk transfected: sc-159001 (B) 293 whole cell lysates.
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