IL-2Rα (B-F2) Antibody: sc-57294

IL-2Rα Background Information
The IL-2 receptor is a multicomponent complex consisting of three subunits, å, ∫ and ©, each of which is required for high-affinity binding of IL-2. The å chain functions primarily in binding IL-2, whereas the ∫ and © chains contribute to IL-2 binding and are essential to IL-2-induced activation of signaling pathways leading to T cell growth. Both IL-4R and IL-7R were initially described as single chain, high-affinity, ligand-binding cytokine receptors. However, it is now well-established that the IL-2R© chain functions as a second subunit of the high-affinity IL-4R and IL-7R receptors. Consequently, the originally described subunits of these latter receptors are now referred to as IL-4Rå and IL-7Rå, respectively, while the common subunit is referred to as ©c. Although the common © chain enhances ligand binding in these three cytokine receptors, it has no capacity to bind these ligands on its own. There is evidence that the ©c chain is also a subunit of IL-13R.