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JNK Antibody (FL): sc-572

 |  Datasheet

(Based on data analysis)

  • JNK Antibody (FL) is a rabbit polyclonal IgG provided at 200 µg/ml
  • produced by immunization with full length (amino acids 1-424) human JNK produced in E. coli
  • recommended for detection of JNK2, JNK1 p46 and JNK3 of mouse, rat, human, zebrafish, Drosophila and Xenopus origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine
  • See 47 citations for JNK Antibody (FL)
 
Full-length JNK protein sequence with immunogen highlighted:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGISVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGC

See additional JNK Antibodies including JNK, JNK1, JNK2 and JNK3.

Also see JNK Inhibitors or JNK Activators for functional analysis of cellular responses to JNK.


Ordering InformationProduct CitationsGene Info
Recommended Support Products:
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WB   IP   IF   IHC(P)  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
JNK Antibody (FL) sc-572 200 µg/ml $279
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
mouse brain extract sc-2253 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
JNK2 (h4): 293T Lysate sc-158651 100 µg/200 µl $205
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104
JNK2 (h): 293T Lysate sc-115269 100 µg/200 µl $205
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MAPK9 5601 5q35.3 NM_002752, NM_139068, NM_139069, NM_139070 P45984
602896
Mouse Mapk10 26414 5 E5 Q61831
N/A
Mouse Mapk8 26419 14 B Q91Y86
N/A
Mouse Mapk9 26420 11 B1.2 Q9WTU6
N/A
 


c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield 10 isoforms through alternative mRNA splicing, including JNK1a1,JNK1b1, JNK2a1, JNK2b1, and JNK3a1, which represent the p46 isoforms, and JNK1a2, JNK1b2, JNK2a2, JNK2b2, and JNK3b2, which represent the p54 isoforms.JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun, and other signaling kinases, including MEKK1 and p38.

JNK Antibody (FL) Product Citations
See how others have used JNK Antibody (FL) and or JNK Antibody (FL) conjugates.


47 total citations
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JNK Antibody (FL) Data
Click on image to enlarge
JNK (FL): sc-572. Immunoperoxidase staining of formalin-fixed, paraffin-embedded normal human skin showing nuclear and cytoplasmic staining of epidermal cells.
Western blot analysis of JNK1 and JNK2 expression in COS cells transfected with JNK1 (A,B,E,F,I,J) or JNK2 (C,D,G,H,K,L). Antibodies tested include JNK1 (F-3): sc-1648 (A-D), JNK1 (C-17)-G: sc-474-G (E-H) and JNK2 (FL): sc-572 (I-L).
JNK (FL): sc-572. Western blot analysis of JNK p54 expression in COS (A) and JNK2-transfected COS (B) whole cell lysates.
JNK (FL): sc-572. Western blot analysis of JNK2 expression in non-transfected: sc-117752 (A) and human JNK2 transfected: sc-115269 (B) 293T whole cell lysates.
JNK (FL): sc-572. Western blot analysis of JNK2 expression in non-transfected: sc-117752 (A) and human JNK2 transfected: sc-158651 (B) 293T whole cell lysates.
JNK (FL): sc-572. Immunoperoxidase staining of formalin fixed, paraffin-embedded human kidney tissue showing cytoplasmic staining of cells in glomeruli and tubules.
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