v-Myb/c-Myb Background Information The Myb family of transcription factors regulates proliferation, differentiation and apoptosis of hematopoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear and binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia and transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, and it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation and may be essential for hematopoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
v-Myb/c-Myb (4E3)
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c-Myb (4E3): sc-56809. Western blot analysis of c-Myb expression in Jurkat (A) and CCRF-CEM (B) nuclear extracts.
v-Myb/c-Myb (4E3): sc-56809. Western blot analysis of c-Myb expression in Jurkat whole cell lysate.
