Welcome to Santa Cruz Biotechnology!
SCBT Home
Home » Transcription Regulators » Id Antibodies » Id3 Antibody (2B11): sc-56712

Id3 Antibody (2B11): sc-56712

 |  Datasheet

(Based on data analysis)
  • Id3 Antibody (2B11) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against amino acids 1-119 of Id3 of mouse origin
  • recommended for detection of Id3 of mouse and human origin by WB, IP and IF
 

See additional Id Antibodies including Id, Id1, Id2, Id3 and Id4.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
Id3 Antibody (2B11) sc-56712 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Id3 siRNA (h) sc-38002 10 µM $258
Id3 siRNA (m) sc-38003 10 µM $258
Id3 siRNA (h2) sc-63297 10 µM $258
Id3 (h)-PR sc-38002-PR 10 µM, 20 µl $23
Id3 (m)-PR sc-38003-PR 10 µM, 20 µl $23
Id3 (h2)-PR sc-63297-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Id3 shRNA Plasmid (h) sc-38002-SH 20 µg $520
Id3 shRNA Plasmid (m) sc-38003-SH 20 µg $520
Id3 shRNA Plasmid (h2) sc-63297-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
Id3 shRNA (h) Lentiviral Particles sc-38002-V 200 µl $625
Id3 shRNA (m) Lentiviral Particles sc-38003-V 200 µl $625
Id3 shRNA (h2) Lentiviral Particles sc-63297-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human ID3 3399 1p36.12 NM_002167 Q02535
 600277
Mouse Id3 15903 4 D3 P41133
 N/A
 

Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.