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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of ACTR-I of human origin
- recommended for detection of ACTR-I of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-5671 P
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Ordering Information
Recommended Support Products:
(click button of application of choice)
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ACVR1 |
90 |
2q24.1 |
NM_001105 |
Q04771
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135100 |
| Mouse |
Acvr1 |
11477 |
2 C1.1 |
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P37172
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N/A |
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ACTR-I Background Information
Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex (1). Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B) (1–6). Both receptor types are highly expressed in brain (5). The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion (5,6).
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ACTR-I (N-15)
Click on image to enlarge
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ACTR-I (N-15): sc-5671. Western blot analysis of ACTR-I expression in SK-N-SH (A) and ES-2 (B) whole cell lysates.
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