PRC1 Background Information Sequential activation and inactivation of Cdk/cyclin complexes regulates the cell cycle. PRC1 (for protein regulating cytokinesis 1) has been identified as a substrate for several Cdks, including Cdc2 and Cdk2. PRC1 binds to the midzone of mitotic spindles during anaphase and is localized to the cell midbody during cytokinesis. Depletion of PRC1 has been shown to prevent cellular cleavage, but it has no effect on nuclear division, demonstrating the importance of PRC1 in mitosis. The yeast homolog of PRC1, Ase1, is essential for spindle assembly, elongation and disassembly during mitosis. Ase1 has been shown to undergo degradation mediated by the APC (anaphase-promoting complex) upon entry into G1 phase.
