epitope corresponding to amino acids 266-357 mapping near the C-terminus of nerve growth factor receptor (NGFR) p75 of human origin
recommended for detection of NGFR p75 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
NGFR p75 Background Information The Trk oncogene encodes a membrane-spanning protein tyrosine kinase, gp140Trk, whose expression is restricted in vivo to neurons of the sensory spinal and cranial ganglia of neural crest origin. Nerve growth factor (NGF) stimulates tyrosine phosphorylation of Trk A in neural cell lines and in embryonic dorsal root ganglia. Tyrosine phosphorylation of Trk by NGF is rapid, specific and occurs with picomolar quantities of factor, indicating that the response is mediated by physiological amounts of NGF, suggesting that Trk A participates in the primary signal transduction mechanism of NGF. An additional component of the Trk A receptor complex, NGFR p75, binds to the neurotrophic factors with low affinity but is required for efficient signaling. NGFR p75 accelerates Trk A activation and may recruit downstream effector molecules to the liganded complex.
NGFR p75 (H-92) Product Citations
See how others have used NGFR p75 (H-92): sc-5634 antibody and or NGFR p75 (H-92) antibody conjugates.
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NGFR p75 (H-92)
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Western blot analysis of NGFR p75 expression in Hs 294T whole cell lysate immunoprecipitated with NGFR p75 (ME20.4): sc-13577 and detected with NGFR p75 (H-92): sc-5634.
