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- mouse monoclonal IgG2a, 200µg/ml
- raised against full length p21 of human origin
- recommended for detection of p21 of human origin by WB, IP, IF, IHC(P) and ELISA; non cross-reactive with other mitotic inhibitors
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p21 Background Information
It is now well established that cyclins play a positive role in promoting cell cycle transitions via their ability to associate with and activate their cognate cyclin-dependent kinases (Cdks). Cdk2 associates with cyclins A, D and E, and has been implicated in the control of the G1 to S phase transition in mammals. A novel Cdk-interacting protein, designated p21, Cip1 or WAF1, has been identified in cyclin A, cyclin D1, cyclin E and Cdk2 immunoprecipitates. p21 is a potent, tight-binding inhibitor of Cdks and can inhibit the phosphorylation of Rb by cyclin A-Cdk 2, cyclin E-Cdk2, cyclin D1-Cdk4 and cyclin D2-Cdk4 complexes. Expression of p21 is inducible by wildtype, but not mutant, p53. The mouse homolog of p21 is designated CAP20. |
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p21 (DCS-60)
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p21 (DCS-60): sc-56335. Western blot analysis of p21 expression in Raji whole cell lysate.
p21 (DCS-60): sc-56335. Western blot analysis of p21 expression in HeLa nuclear extract.
p21 (DCS-60): sc-56335. Western blot analysis of p21 expression in C32 whole cell lysate.
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