cyclin E Background Information Cyclins were first identified in invertebrates as proteins that oscillate dramatically through the cell cycle. These proteins have been well conserved through evolution and play a critical role in regulation of cell division. cyclin E, along with the three cyclin D proteins and cyclin C, has been shown to represent a putative G1 cyclin on the basis of its cyclic pattern of mRNA expression, with maximal levels being detected near the G1/S boundary. cyclin E has been found to be associated with the transcription factor E2F in a temporally regulated manner. The cyclin E/E2F complex is detected primarily during the G1 phase of the cell cycle and decreases as cells enter S phase. E2F is known to be a critical transcription factor for expression of several S phase specific proteins.
cyclin E (13A3) Product Citations
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cyclin E (13A3)
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cyclin E (13A3): sc-56310. Western blot analysis of cyclin E expression in MOLT-4 (A), K-562 (B), HeLa (C) and IMR-32 (D) nuclear extracts and MEG-01 (E) and JEG-3 (F) whole cell lysates.
cyclin E (13A3): sc-56310. Western blot analysis of cyclin E expression in non-transfected: sc-117752 (A) and human cyclin E transfected: sc-170464 (B) 293T whole cell lysates.
