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- rabbit polyclonal IgG, 200 µg/ml
- epitope mapping at the C-terminus of GRK 3 of cow origin
- recommended for detection of GRK 3 of mouse, rat, human and cow origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-563 P
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Ordering InformationProduct Citations
Recommended Support Products:
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
ADRBK2 |
157 |
22q11.23 |
NM_005160 |
P35626
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109636 |
| Mouse |
Adrbk2 |
320129 |
5 F |
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Q3UYH7
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N/A |
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GRK 3 Background Information
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first class is comprised of the second messenger-regulated kinases, such as c-AMP dependent protein kinase A and protein kinase C. The second class includes the G protein-coupled receptor kinases (GRKs). At least seven members of the GRK family have been identified. These include rhodopsin kinase (GRK 1), two forms of ∫-adrenergic receptor kinase: GRK 2 (∫ARK, ∫ARK1) and GRK 3 (∫ARK2), IT-11 (GRK 4), GRK 5, GRK 6 and GRK 7. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.
| GRK 3 (C-14) Product Citations |
See how others have used GRK 3 (C-14): sc-563 antibody and or GRK 3 (C-14) antibody conjugates.
15 total citations Loading citations.
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GRK 3 (C-14)
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GRK 3 (C-14): sc-563. Western blot analysis of GRK 3 expression in BJAB (A), Ramos (B), HL-60 (C) and MOLT-4 (D) whole cell lysates.
GRK 3 siRNA (h): sc-35514. Western blot analysis of GRK 3 expression in non-transfected control (A) and GRK 3 siRNA transfected (B) HeLa cells. Blot probed with GRK 3 (C-14): sc-563. Actin (I-19): sc-1616 used as specificity and loading control. GRK 3 (C-14): sc-563. Western blot analysis of GRK 3 expression in non-transfected: sc-110760 (A) and mouse GRK 3 transfected: sc-178704 (B) 293 whole cell lysates. GRK 3 (C-14): sc-563. Western blot analysis of GRK 3 expression in non-transfected: sc-110760 (A) and human GRK 3 transfected: sc-158577 (B) 293 whole cell lysates. GRK 3 (C-14): sc-563. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cervix tissue showing cytoplasmic staining of squamous epithelial cells.
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