Chk2 Antibody (DCS-270): sc-56296
- Chk2 Antibody (DCS-270) is a mouse monoclonal IgG2a κ, cited in 14 publications, provided at 200 µg/ml
- raised against a Chk2 fusion protein of human origin
- recommended for detection of Chk2 of human origin by WB, IP, IF and IHC(P)
- See Chk2 (A-11): sc-17747 for Chk2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Chk2 Antibody (DCS-270). This work is in progress.
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Chk2 Antibody (DCS-270) is a mouse monoclonal IgG2a antibody that detects Chk2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Chk2 plays a critical role in the cellular response to DNA damage, functioning as a key regulator in the G2 DNA damage checkpoint. Upon DNA damage, Chk2 is activated and phosphorylates Cdc25C, which inhibits its phosphatase activity, thereby preventing the activation of cyclin-dependent kinases and blocking the progression of mitosis. This mechanism is vital for maintaining genomic stability, as it allows the cell time to repair DNA before division, thus preventing the propagation of damaged DNA. Additionally, Chk2 interacts with various proteins involved in the DNA damage response, including p53, further underscoring its importance in tumor suppression and cellular integrity. Anti-Chk2 antibody (DCS-270) is an essential tool for researchers studying cell cycle regulation and the mechanisms of DNA damage repair in human cells.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chk2 Antibody (DCS-270) | sc-56296 | 200 µg/ml | $316.00 |