WRN (H-300) Antibody: sc-5629

WRN Background Information
Werner’s Syndrome (WS), also called adult progeria, is an inherited, autosomal recessive disorder that is most common in families from regions of Japan where consanguineous marriages occur frequently (1-3). WS is characterized by premature aging and the early onset of age-related diseases and commonly results in cancer (4,5). The gene responsible for Werner’s Syndrome, WRN, has been mapped to the short arm of chromosome 8, 8p11.2-p12 and the subsequent cloning of the gene has reveled a predicted protein of 1432 amino acids in length, that bears significant sequence homology with DNA helicases (6,7). Four mutations in WRN have been identified in patients afflicted with WS (7). Two of the mutations involve mRNA splice-junctions. Of these two mutations, one was found in 60 percent of the individuals examined (7). This mutation is predicted to cause a frameshift which results in a truncated WRN protein (7).