Cdc25C Background Information Cell cycle events are regulated by the sequential activation and deactivation of cyclin-dependent kinases (Cdks), including Cdk2 and Cdc2. Cdk2 in complexes with cyclin E and cyclin A appears necessary for the onset and progression of DNA replication, while the Cdc2 kinase in complexes with cyclin A or cyclin B is required for the initiation of cell division. Wee 1 has been identified as a protein kinase that suppresses the entry into mitosis by mediating inhibiting tyrosine phosphorylation of Cdc2 p34. In contrast, members of the Cdc25 family of protein phosphatases function as mitotic activators by dephosphorylation of Cdc2 p34 on regulatory tyrosine and possibly threonine residues. The Cdc25 gene family consists of at least three members that share approximately 40% identity in their most conserved carboxy-terminal sequences.
Cdc25C (H-150) Product Citations
See how others have used Cdc25C (H-150): sc-5620 antibody and or Cdc25C (H-150) antibody conjugates.
6 total citations
Loading citations.
Cdc25C (H-150)
Click on image to enlarge
Cdc25C (H-150): sc-5620. Western blot analysis of human recombinant Cdc25C fusion protein.
Cdc25C (H-150): sc-5620. Western blot analysis of Cdc25C expression in K-562 (A), PC-3 (B), Raji (C), untreated Hela (D) and nocodozole-treated Hela (E) whole cell lysates.
Cdc25C (H-150): sc-5620. Western blot analysis of Cdc25C expression in non-transfected 293T: sc-117752 (A), human Cdc25C transfected 293T: sc-177045 (B) and Raji (C) whole cell lysates.
