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home » Cell Cycle Proteins » Cdc Antibody / Cdc Antibodies » Cdc37 (H-271): sc-5617

Cdc37 (H-271) Antibody: sc-5617

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 108-378 of Cdc37 of human origin
  • recommended for detection of Cdc37 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine, bovine and porcine
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human CDC37 11140 19p13.2 NM_007065 Q16543
 605065
Mouse Cdc37 12539 9 A3 Q61081
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc37 (H-271) sc-5617 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc37 siRNA (h) sc-29255 10 µM $258
Cdc37 siRNA (m) sc-35043 10 µM $258
Cdc37 (h)-PR sc-29255-PR 10 µM $23
Cdc37 (m)-PR sc-35043-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc37 shRNA Plasmid (h) sc-29255-SH 20 µg $520
Cdc37 shRNA Plasmid (m) sc-35043-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Cdc37 shRNA (h) Lentiviral Particles sc-29255-V 200 µl $625
Cdc37 shRNA (m) Lentiviral Particles sc-35043-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Jurkat Whole Cell Lysate sc-2204 500 µg/200 µl $104
CTLL-2 Cell Lysate sc-2242 500 µg/200 µl $104
KNRK Whole Cell Lysate sc-2214 500 µg/200 µl $104
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
LNCaP Cell Lysate sc-2231 500 µg/200 µl $104
Cdc37 (h3): 293T Lysate sc-174911 100µg/200µl $205
A-431 Whole Cell Lysate sc-2201 500 µg/200 µl $104
Cdc37 (h4): 293T Lysate sc-174915 100µg/200µl $205

Cdc37 Background Information
Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Cdc37 (H-271) Product Citations
See how others have used Cdc37 (H-271): sc-5617 antibody and or Cdc37 (H-271) antibody conjugates.


2 total citations
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Cdc37 (H-271)
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sc-5617
Cdc37 (H-271): sc-5617. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic and nuclear staining (A). Immunofluorescence staining of methanol-fixed KNRK cells showing cytoplasmic localization (B).
sc-5617
Cdc37 (H-271): sc-5617. Western blot analysis of human recombinant Cdc37 fusion protein.
sc-5617
Cdc37 (H-271): sc-5617. Western blot analysis of Cdc37 expression in A-431 (A), Jurkat (B), CTLL-2 (C), K-562 (D) and LNCaP (E) whole cell lysates and rat testis (F) tissue extract.
sc-5617
Cdc37 siRNA (h): sc-29255. Immunofluorescence staining of methanol-fixed, control HeLa (A) and Cdc37 siRNA silenced HeLa (B) cells showing diminished nuclear staining in the siRNA silenced cells. Cells probed with Cdc37 (H-271): sc-5617.
sc-5617
Cdc37 (H-271): sc-5617. Western blot analysis of Cdc37 expression in non-transfected 293T: sc-117752 (A), human Cdc37 transfected 293T: sc-174915 (B) and K-562 (C) whole cell lysates.
sc-5617
Cdc37 (H-271): sc-5617. Western blot analysis of Cdc37 expression in non-transfected: sc-117752 (A) and human Cdc37 transfected: sc-174911 (B) 293T whole cell lysates.
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