DNA Ligase III Background Information DNA ligase is a type of ligase that can link together DNA strands that have double-strand breaks. DNA ligase functions in both DNA repair and DNA replication. It is utilized in molecular biology laboratories for recombination experiments. In mammals, the four specific types of DNA ligase are known as DNA Ligase I, II, III and IV. DNA Ligase I ligates Okazaki fragments during lagging strand DNA replication and some recombinant fragments. DNA Ligase II is an alternatively spliced form of DNA Ligase III found in non-dividing cells. DNA ligase III complexes with the DNA repair protein XRCC1 to function in sealing base excision mutations and recombinant fragments. DNA Ligase IV complexes with XRCC4 and catalyzes the final step in the non-homologous end joining DNA double-strand break repair pathway.
DNA Ligase III (6G9)
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DNA Ligase III (6G9): sc-56089. Western blot analysis of DNA Ligase III expression in HeLa (A) and K-562 (B) whole cell lysates.
DNA Ligase III (6G9): sc-56089. Western blot analysis of DNA Ligase III expression in non-transfected: sc-117752 (A) and human DNA Ligase III transfected: sc-117222 (B) 293T whole cell lysates.
DNA Ligase III (6G9): sc-56089. Western blot analysis of DNA Ligase III expression in non-transfected: sc-117752 (A) and mouse DNA Ligase III transfected: sc-125252 (B) 293T whole cell lysates.
