Jagged2 Background Information The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Ligands for Notch include Jagged1, Jagged2 and Delta. Jagged is a membrane protein and can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. It is involved in mammalian cardiovascular development and in cell-fate decisions during hematopoiesis. Jagged is expressed in adult and fetal tissues, and the expression is up-regulated in cervical squamous cell carcinoma. Familial Tetralogy of Fallot, the most common form of complex congenital heart disease, is caused by a mutation in the JAG1 gene.
Jagged2 (H-143) Product Citations
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Jagged2 (H-143)
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Jagged2 (H-143): sc-5604. Western blot analysis of human recombinant Jagged2 fusion protein.
Jagged2 (H-143): sc-5604. Western blot analysis of Jagged2 expression in untreated Jurkat (A) and GM-CSF-treated Jurkat (B) whole cell lysates.
Jagged2 (H-143): sc-5604. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic staining of macropages and peumocytes cells.
