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caspase-11 Antibody (17D9): sc-56038

 |  Datasheet

(Based on data analysis)
  • caspase-11 Antibody (17D9) is a rat monoclonal IgG2a provided at 200 µg/ml
  • raised against recombinant caspase-11 of mouse origin
  • recommended for detection of caspase-11 of mouse and rat origin by WB, IP and IF
 

See additional Caspase Antibodies including caspase-14, caspase-12, caspase-11, caspase-10, caspase-9, caspase-8, caspase-7, caspase-6, caspase-5, caspase-4, caspase-3, caspase-2, caspase-1, Caspase and caspase-16.

Also see caspase-11 Inhibitors for functional analysis of cellular responses to caspase-11.


Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
caspase-11 Antibody (17D9) sc-56038 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
caspase-11 siRNA (m) sc-37363 10 µM $258
caspase-11 (m)-PR sc-37363-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
caspase-11 shRNA Plasmid (m) sc-37363-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
caspase-11 shRNA (m) Lentiviral Particles sc-37363-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Casp4 12363 9 A1 P70343
 N/A
 

Caspase-11 plays a crucial role in OLG death and pathogenesis in experimental autoimmune encephalomyelitis (EAE). Caspase-11 also leads to the synthesis of the functional form of the cytokine interleukin-1beta. Caspases are a family of mammalian proteases related to the ced-3 gene of Caenorhabditis elegans. These ced-3 orthologs mediate many of the morphological and biochemical features of apoptosis, including structural dismantling of cell bodies and nuclei, fragmentation of genomic DNA, destruction of regulatory proteins, and propagation of other pro-apoptotic molecules. Based on their substrate specificities and DNA sequence homologies, the 14 currently identified caspases may be divided into three groups: apoptotic initiators, apoptotic executioners and inflammatory mediators. Upon activation, caspases appear to play an important role in sequelae of traumatic brain injury, spinal cord injury and cerebral iischemia. In addition, they may also play a role in mediating cell death in chronic neurodegenerative conditions such as Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis.