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home » Transcription Regulators » SREBP Antibody / SREBP Antibodies » SREBP-2 (H-164): sc-5603

SREBP-2 (H-164) Antibody: sc-5603

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 812-975 mapping to an internal region of SREBP-2 of human origin
  • recommended for detection of SREBP-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
 
Additional SREBP Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SREBF2 6721 22q13.2 NM_004599 Q12772
 600481
Mouse Srebf2 20788 15 E1 Q3U1N2
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
SREBP-2 (H-164) sc-5603 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SREBP-2 siRNA (h) sc-36559 10 µM $258
SREBP-2 siRNA (m) sc-36560 10 µM $258
SREBP-2 (h)-PR sc-36559-PR 10 µM $23
SREBP-2 (m)-PR sc-36560-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SREBP-2 shRNA Plasmid (h) sc-36559-SH 20 µg $520
SREBP-2 shRNA Plasmid (m) sc-36560-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
SREBP-2 shRNA (h) Lentiviral Particles sc-36559-V 200 µl $625
SREBP-2 shRNA (m) Lentiviral Particles sc-36560-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
LNCaP Cell Lysate sc-2231 500 µg/200 µl $104
PC-3 Cell Lysate sc-2220 500 µg/200 µl $104
KNRK nuclear extract sc-2141 1000 µg $143
U-937 nuclear extract sc-2156 1000 µg $143

SREBP-2 Background Information
The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a 10 base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SRE-binding proteins (SREBPs) have been identified, including two basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.

SREBP-2 (H-164) Product Citations
See how others have used SREBP-2 (H-164): sc-5603 antibody and or SREBP-2 (H-164) antibody conjugates.


6 total citations
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SREBP-2 (H-164)
Click on image to enlarge
sc-5603
SREBP-2 (H-164): sc-5603. Immunofluorescence staining of methanol-fixed U-937 cells showing cytoplasmic localization.
sc-5603
SREBP-2 (H-164): sc-5603. Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse testis tissue showing membrane and cytoplasmic localization.
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