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home » Transport and Trafficking » CRM Antibody / CRM Antibodies » CRM1 (H-300): sc-5595

CRM1 (H-300) Antibody: sc-5595

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 772-1071 mapping at the C-terminus of CRM1 of human origin
  • recommended for detection of CRM1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
 
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Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human XPO1 7514 2p15 NM_003400 O14980
 602559
Mouse Xpo1 103573 11 A3.2 Q6P5F9
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
CRM1 (H-300) sc-5595 200 µg/ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CRM1 siRNA (h) sc-35116 10 µM $258
CRM1 siRNA (m) sc-35117 10 µM $258
CRM1 (h)-PR sc-35116-PR 10 µM $23
CRM1 (m)-PR sc-35117-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CRM1 shRNA Plasmid (h) sc-35116-SH 20 µg $520
CRM1 shRNA Plasmid (m) sc-35117-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
CRM1 shRNA (h) Lentiviral Particles sc-35116-V 200 µl $625
CRM1 shRNA (m) Lentiviral Particles sc-35117-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa nuclear extract sc-2120 1000 µg $143
A-431 nuclear extract sc-2122 1000 µg $143
K-562 nuclear extract sc-2130 1000 µg $143
Jurkat nuclear extract sc-2132 1000 µg $143
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104
IMR-32 Cell Lysate sc-2409 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
NIH/3T3 Whole Cell Lysate sc-2210 500 µg/200 µl $104

CRM1 Background Information
Protein transport across the nucleus is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Two cytosolic factors centrally involved in the recognition and docking process are the karyopherin alpha1 and karyopherin beta1 subunits. p62 glycoprotein is a nucleoporin that is not only involved in the nuclear import of proteins, but also the export of nascent mRNA strands. NTF2 (nuclear transport factor 2) interacts with nucleoporin p62 as a homodimer composed of two monomers, and may be an obligate component of functional p62. CRM1 has been shown to be an export receptor for leucine-rich proteins that contain the nuclear export signal (NES).

CRM1 (H-300) Product Citations
See how others have used CRM1 (H-300): sc-5595 antibody and or CRM1 (H-300) antibody conjugates.


21 total citations
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CRM1 (H-300)
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sc-5595
CRM1 (H-300): sc-5595. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear staining.
sc-5595
CRM1 (H-300): sc-5595. Western blot analysis of CRM1 expression in HeLa (A) and NIH/3T3 (B) whole cell lysates.
sc-5595
CRM1 siRNA (h): sc-35116. Immunofluorescence staining of methanol-fixed, control HeLa (A) and CRM1 siRNA silenced HeLa (B) cells showing diminished nuclear staining in the siRNA silenced cells. Cells probed with CRM1 (H-300): sc-5595.
sc-5595
CRM1 (H-300): sc-5595. Immunofluorescence staining of normal mouse intestine frozen section showing nuclear staining.
sc-5595
CRM1 (H-300): sc-5595. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing nuclear and cytoplasmic staining in decidual and trophoblastic cells (low and high magni?fication). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-5595
CRM1 (H-300): sc-5595. Western blot analysis of CRM1 expression in non-transfected: sc-117752 (A) and mouse CRM1 transfected: sc-125173 (B) 293T whole cell lysates and HeLa nuclear extract (C).
sc-5595
CRM1 (H-300): sc-5595. Western blot analysis of CRM1 expression in HeLa (A), A-431 (B), K-562 (C) and Jurkat (D) nuclear extracts.
sc-5595
CRM1 (H-300): sc-5595. Western blot analysis of CRM1 expression in non-transfected 293T: sc-117752 (A), human CRM1 transfected 293T: sc-171482 (B) and K-562 (C) whole cell lysates.
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