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home » Tumor Suppressors/Apoptosis » VHL Antibody / VHL Antibodies » VHL (FL-181): sc-5575

VHL (FL-181) Antibody: sc-5575

  |  Datasheet
  • rabbit polyclonal IgG, 200 µg/ml
  • epitope corresponding to amino acids 1-181 representing full length von Hippel-Lindau tumor suppressor protein (VHL) of mouse origin
  • recommended for detection of VHL of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • agarose conjugate for IP studies, sc-5575 AC, 500 µg/0.25 ml agarose
 
Additional VHL Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   IHC(P)   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human VHL 7428 3p25.3 NM_000551, NM_198156 P40337
 608537
Mouse Vhl 22346 6 E3 P40338
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
VHL (FL-181) sc-5575 200 µg/ml $279
VHL (FL-181) AC sc-5575 AC 500µg/ml, 25%ag $366
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
VHL siRNA (h) sc-36816 10 µM $258
VHL siRNA (m) sc-36817 10 µM $258
VHL (h)-PR sc-36816-PR 10 µM $23
VHL (m)-PR sc-36817-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
VHL shRNA Plasmid (h) sc-36816-SH 20 µg $520
VHL shRNA Plasmid (m) sc-36817-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
VHL shRNA (h) Lentiviral Particles sc-36816-V 200 µl $625
VHL shRNA (m) Lentiviral Particles sc-36817-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
F9 Cell Lysate sc-2245 500 µg/200 µl $104
mouse brain extract sc-2253 500 µg/200 µl $104
3611-RF nuclear extract sc-2143 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143
Hep G2 Cell Lysate sc-2227 500 µg/200 µl $104
mouse testis extract sc-2405 500 µg/200 µl $104

VHL Background Information
Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinoma, hemangioblastoma of the central nervous system and pheochromocytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. Different isoforms of VHL have been observed, encoded by alternatively spliced transcript variants. The molecular weight of each isoform varies between species.

VHL (FL-181) Product Citations
See how others have used VHL (FL-181): sc-5575 antibody and or VHL (FL-181) antibody conjugates.


15 total citations
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VHL (FL-181)
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sc-5575
VHL (FL-181): sc-5575. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human kidney tissue showing membrane and cytoplasmic staining.
sc-5575
VHL (FL-181): sc-5575. Western blot analysis of VHL expression in F9 whole cell lysate.
sc-5575
VHL (FL-181): sc-5575. Immunofluorescence staining of methanol-fixed F9 cells showing membrane localization.
sc-5575
VHL (FL-181): sc-5575. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells at high magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
sc-5575
VHL (FL-181): sc-5575. Immunoperoxidase staining of formalin fixed, paraffin-embedded human gall bladder tissue showing cytoplasmic staining of glandular cells at low magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
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