epitope mapping at the N-terminus of PADI3 of human origin
recommended for detection of PADI3 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine and porcine
PADI3 Background Information The protein arginine deiminase (PAD) family of proteins, often referred to as peptidylarginine deiminases, catalyze the deimination of arginine residues of proteins. The PAD proteins, designated PADI1-4, are cytoplasmic proteins primarily detected in eosinophils and neutrophils. In the presence of calcium, PAD proteins act as catalysts for the post-translational modification reaction that converts methylarginine to citrulline. PADI3 (peptidyl arginine deiminase, type III), also called PAD3 or PDI3, is a cytoplasmic protein that modulates Filaggrin and Trichohyalin (proteins involved in hair structure) during formation of the hair follicle. Expressed in hair and at very low levels in the epidermis, PADI3 is thought to interact with PADI1 and participate in terminal differentiation of the epidermis.
