epitope mapping within an internal region of IDH3G of human origin
recommended for detection of IDH3G of human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
IDH3G Background Information IDH3G (Isocitrate dehydrogenase [NAD] subunit g (mitochondrial), NAD(+)-specific ICDH) is a 393 amino acid protein encoded by the human gene IDH3G. IDH3G belongs to the isocitrate and isopropylmalate dehydrogenases family and can bind one magnesium or manganese ion per subunit. It is usually found in the mitochondrion as a heterooligomer of subunits a, b, and g in the apparent ratio of 2:1:1. Human NAD-dependent isocitrate dehydrogenase (IDH) is allosterically activated by ADP by lowering the Km for isocitrate. NAD-dependent isocitrate dehydrogenase is a tricarboxylic acid cycle enzyme that produces 2-oxoglutarate, an organic acid required by the glutamine synthetase/glutamate synthase cycle to assimilate ammonium.
IDH3G (L-20)
Click on image to enlarge
IDH3G (L-20): sc-55680. Western blot analysis of IDH3G expression in SK-BR-3 whole cell lysate.
IDH3G (L-20): sc-55680. Western blot analysis of IDH3G expression in SK-BR-3 (A), HT-1080 (B), HeLa (C) and MCF7 (D) whole cell lysates.
