epitope mapping within an internal region of IDH1 and IDH2 of human origin
recommended for detection of IDH1/2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
IDH2 Background Information IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), also designated NADP+-specific ICDH; isocitrate dehydrogenase, mitochondrial; and oxalosuccinate decarboxylase, is a 452 amino acid enzyme encoded by the human gene IDH2. IDH2 belongs to the isocitrate and isopropylmalate dehydrogenases family and contains two nucleotide binding regions. IDH2 is involved in the reduction of NADP+ to NADPH and maintains the supply of glutathione (GSH) in mitochondria. It is believed to play a role in intermediary metabolism and energy production. IDH2 also tightly associates with the pyruvate dehydrogenase complex. IDH2 is found in the mitochondrion as a homodimer and can bind one magnesium or manganese ion per subunit.
IDH1/2 (W-16) Product Citations
See how others have used IDH1/2 (W-16): sc-55668 antibody and or IDH1/2 (W-16) antibody conjugates.
1 total citations
Loading citations.
IDH1/2 (W-16)
Click on image to enlarge
IDH2 (W-16): sc-55668. Western blot analysis of IDH2 expression in rat heart (A) and mouse heart (B) tissue extracts.
IDH2 (W-16): sc-55668. Western blot analysis of IDH2 expression in DU 145 whole cell lysate.
IDH2 (W-16): sc-55668. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.
