epitope corresponding to amino acids 1-279 mapping at the N-terminus of cyclin I of human origin
recommended for detection of cyclin I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
cyclin I Background Information Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2-cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N-terminal cyclin box and a C-terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Cyclin I shares highest sequence similarity to cyclins G and E and is most highly expressed in skeletal muscle, heart and brain.
cyclin I (H-279) Product Citations
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cyclin I (H-279)
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cyclin I (H-279): sc-5547. Western blot analysis of cyclin I expression in rat skeletal muscle (A) and mouse brain (B) extracts.
cyclin I (H-279): sc-5547. Immunofluor?escence staining of normal mouse intestine frozen section showing nuclear and cytoplasmic staining.
cyclin I (H-279): sc-5547. Immunoperoxidase staining of formalin fixed, paraffin-embedded human prostate cancer tissue showing cytoplasmic staining of tumor cells at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.
cyclin I (H-279): sc-5547. Western blot analysis of cyclin I expression in non-transfected: sc-117752 (A) and mouse cyclin I transfected: sc-119548 (B) 293T whole cell lysates.
