santa cruz biotechnology, inc.
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TSC-22 D4 (N-15) Antibody: sc-55412 |
| Datasheet |
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- goat polyclonal IgG, 200µg/ml
- epitope mapping near the N-terminus of TSC-22 D4 of human origin
- recommended for detection of TSC-22 D4 of human origin by WB, IP, IF and ELISA
- blocking peptide, sc-55412 P
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
TSC22D4 |
81628 |
7q22.1 |
NM_030935 |
Q9Y3Q8
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n/a |
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TSC-22 D4 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation, as well as cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in both the TGF-beta pathway and the PPAR© signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, implies an antiproliferative role for TSC-22. TSC-22 D4 (TSC22 domain family protein 4), also known as TILZ2 or THG-1 is a 395 amino acid protein that is related to TSC-22 and functions as a transcriptional repressor. |
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TSC-22 D4 (N-15)
Click on image to enlarge
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TSC-22 D4 (N-15): sc-55412. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
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