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home » Transcription Regulators » TSC-22 Antibody / TSC-22 Antibodies » TSC-22 D4 (A-20): sc-55410

TSC-22 D4 (A-20) Antibody: sc-55410

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping within an internal region of TSC-22 D4 of mouse origin
  • recommended for detection of TSC-22 D4 of mouse and rat origin by IP and ELISA; also reactive with additional species, including equine, canine and porcine
  • blocking peptide, sc-55410 P
 
Additional TSC-22 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
IP   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Mouse Tsc22d4 78829 5 G2 Q9EQN3
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D4 (A-20) sc-55410 200 µg/ml $279
TSC-22 D4 (A-20) P sc-55410 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D4 siRNA (m) sc-63174 10 µM $258
TSC-22 D4 (m)-PR sc-63174-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D4 shRNA Plasmid (m) sc-63174-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D4 shRNA (m) Lentiviral Particles sc-63174-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D4 (m): 293T Lysate sc-124325 100µg/200µl $205
K-562 Whole Cell Lysate sc-2203 500 µg/200 µl $104

TSC-22 D4 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation, as well as cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in both the TGF-beta pathway and the PPAR© signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, implies an antiproliferative role for TSC-22. TSC-22 D4 (TSC22 domain family protein 4), also known as TILZ2 or THG-1 is a 395 amino acid protein that is related to TSC-22 and functions as a transcriptional repressor.