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home » Transcription Regulators » TSC-22 Antibody / TSC-22 Antibodies » TSC-22 D2 (C-20): sc-55406

TSC-22 D2 (C-20) Antibody: sc-55406

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping at the C-terminus of TSC-22 D2 of human origin
  • recommended for detection of TSC-22 D2 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
  • blocking peptide, sc-55406 P
 
Additional TSC-22 Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human TSC22D2 9819 3q25.1 NM_014779 O75157
 n/a
Mouse Tsc22d2 72033 3 D NP_001074698
 N/A
 
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D2 (C-20) sc-55406 200 µg/ml $279
TSC-22 D2 (C-20) P sc-55406 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D2 siRNA (h) sc-63171 10 µM $258
TSC-22 D2 siRNA (m) sc-63172 10 µM $258
TSC-22 D2 (h)-PR sc-63171-PR 10 µM $23
TSC-22 D2 (m)-PR sc-63172-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D2 shRNA Plasmid (h) sc-63171-SH 20 µg $520
TSC-22 D2 shRNA Plasmid (m) sc-63172-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
TSC-22 D2 shRNA (h) Lentiviral Particles sc-63171-V 200 µl $625
TSC-22 D2 shRNA (m) Lentiviral Particles sc-63172-V 200 µl $625

TSC-22 D2 Background Information
Transforming growth factor-beta-stimulated clone-22 (TSC-22) acts as a transcriptional regulator to modulate cell growth and differentiation, as well as cell death. TSC-22 contains a leucine zipper domain as well as a nuclear export signal, resulting in cytoplasmic localization in living cells. However, concomitant with the induction of apoptosis, TSC-22 translocates from the cytoplasm to the nucleus and shows transcriptional regulatory activity. TSC-22 acts as a major downstream component in both the TGF-beta pathway and the PPAR© signaling pathway. The association of these two pathways with tumor suppression, and the significant downregulation of TSC-22 mRNA in various cancer types, implies an antiproliferative role for TSC-22. TSC-22 D2 (TSC22 domain family protein 2), also known as TILZ4, is a 780 amino acid protein that is related to TSC-22 and is involved in adaptation of renal cells to hypertonicity, suggesting a possible role in signal transduction. Three isoforms exist due to alternative splicing events.