santa cruz biotechnology, inc.
SCBT Logo

Welcome!        Items in Cart     Quick Order
home » Synthesis and Degradation » PDE Antibody / PDE Antibodies » PDE1C (W-16): sc-54940

PDE1C (W-16) Antibody: sc-54940

  |  Datasheet
  • goat polyclonal IgG, 200µg/ml
  • epitope mapping within an internal region of PDE1C of rat origin
  • recommended for detection of PDE1C of h, r origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
  • blocking peptide, sc-54940 P
 
Additional PDE Antibodies ...
 
Ordering Information
Recommended Support Products:
(click button of application of choice)
WB   IP   IF   siRNA  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PDE1C 5137 7p14.3 NM_005020 NP_005011
 602987
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PDE1C (W-16) sc-54940 200 µg/ml $279
PDE1C (W-16) P sc-54940 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDE1C siRNA (h) sc-62765 10 µM $258
PDE1C (h)-PR sc-62765-PR 10 µM $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDE1C shRNA Plasmid (h) sc-62765-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PDE1C shRNA (h) Lentiviral Particles sc-62765-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
rat cerebellum extract sc-2398 500 µg/200 µl $104
PDE1C (h): 293T Lysate sc-171529 100µg/200µl $205
rat brain extract sc-2392 500 µg/200 µl $104

PDE1C Background Information
Phosphodiesterases (PDEs, also designated cyclic nucleotide phosphodiesterase) are important for the downregulation of intracellular levels of the second messengers cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). The PDE1 family are calmodulin-dependent (CaM-PDE) proteins that undergo stimulation through a calcium-calmodulin complex and function to hydrolyze cAMP to 5'AMP and cGMP to 5'GMP. PDE1C (phosphodiesterase 1C), also known as HCAM3, is a widely expressed protein that has a high affinity for both cAMP and cGMP. Two isoforms, designated PDE1C1 and PDE1C2, exist due to alternative splicing at the C-terminus. While both isoforms are expressed in low levels throughout the body, PDE1C2 is expressed predominately in the brain and heart, while PDE1C1 is expressed predominately in the brain, heart and lung.
PDE1C (W-16)
Click on image to enlarge
sc-54940
PDE1C (W-16): sc-54940. Western blot analysis of PDE1C expression in rat cerebellum tissue extract.
sc-54940
PDE1C (W-16): sc-54940. Western blot analysis of PDE1C expression in rat brain tissue extract.
sc-54940
PDE1C (W-16): sc-54940. Western blot analysis of PDE1C expression in non-transfected: sc-117752 (A) and human PDE1C transfected: sc-171529 (B) 293T whole cell lysates and rat brain tissue extract (C).
sc-54940
PDE1C (W-16): sc-54940. Western blot analysis of PDE1C expression in non-transfected: sc-110760 (A) and human PDE1C transfected: sc-158826 (B) 293 whole cell lysates.
Download
Datasheets
Get Adobe Acrobat Reader