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home » Transcription Regulators » Small Nuclear Ribonucleoprotein-Associated Protein Antibody / Small Nuclear Ribonucleoprotein-Associated Protein Antibodies » Sm B/B'/N (N-18): sc-5485

Sm B/B'/N (N-18) Antibody: sc-5485

  |  Datasheet
  • goat polyclonal IgG, 200 µg/ml
  • epitope mapping at the N-terminus of Sm B of human origin
  • recommended for detection of Sm B, Sm B' and Sm N of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-5485 P
 
Additional Small Nuclear Ribonucleoprotein-Associated Protein Antibodies ...
 
Ordering InformationProduct Citations
Recommended Support Products:
(click button of application of choice)
WB   IP   IF  
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human SNRPB 6628 20p13 NM_003091, NM_198216 P14678
 182282
Human SNRPN 6638 15q11.2 NM_003097, NM_022805, NM_022806, NM_022807, NM_022808 P63162
 182279
Mouse Snrpb 20638 2 F1 P27048
 N/A
Mouse Snrpn 20646 7 C P63163
 N/A
 
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Sm B/B'/N (N-18) sc-5485 200 µg/ml $279
Sm B/B’/N (N-18) P sc-5485 P
(peptide)
 100 µg/0.5 ml $61
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
K-562 nuclear extract sc-2130 1000 µg $143
HeLa nuclear extract sc-2120 1000 µg $143
KNRK nuclear extract sc-2141 1000 µg $143

Sm B/B'/N Background Information
mRNA precursors are processed in the spliceosome, where introns are excised to form continuous coding sequences. The major components of the spliceosome are RNA-protein complexes called snRNPs (small nuclear ribonucleoprotein particles) (1). The core proteins that are common to all snRNPs are called the Sm proteins, and are designated B, B’, D1, D2, D3, E, F and G (2). Antibodies recognizing Sm proteins are frequently generated in autoimmune diseases, including in patients with systemic lupus erythematosus (3). Sm proteins are characterized by a conserved Sm sequence motif in two parts, Sm1 and Sm2, which are separated by a variable region (4, 5).

Sm B/B'/N (N-18) Product Citations
See how others have used Sm B/B'/N (N-18): sc-5485 antibody and or Sm B/B'/N (N-18) antibody conjugates.


4 total citations
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Sm B/B'/N (N-18)
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sc-5485
Sm B/B/N (N-18): sc-5485. Western blot analysis of Sm B expression in K-562 nuclear extract.
sc-5485
Sm B/B'/N (N-18): sc-5485. Western blot analysis of Sm B/B'/N expression in non-transfected: sc-117752 (A) and human Sm B/B'/N transfected: sc-114542 (B) 293T whole cell lysates.
sc-5485
Sm B/B/N (N-18): sc-5485. Western blot analysis of Sm B/B/N expression in K-562 nuclear extract.
sc-5485
Sm B/B'/N (N-18): sc-5485. Western blot analysis of Sm B/B/N expression in non-transfected: sc-117752 (A) and human Sm B/B/N transfected: sc-114542 (B) 293T whole cell lysates and HeLa nuclear extract (C).
sc-5485
Sm B/B/N (N-18): sc-5485. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic and nuclear localization.
sc-5485
Sm B/B'/N (N-18): sc-5485. Western blot analysis of Sm B/B'/N expression in K-562 (A), HeLa (B) and KNRK (C) nuclear extracts.
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