MAS1 Background Information The proto-oncogene MAS1 is a G protein-coupled receptor located on the plasma membrane. In transfected NIH/3T3 cells, MAS1 has a weak focus-inducing activity. MAS1 is an antagonist of the Angiotensin II type 1 (AT1) receptor, inhibiting the actions of Angiotensin II. MAS1 localizes to cardiomyocytes of the heart in mice. Mice deficient for MAS1 demonstrate a lower systolic tension and heart rate. The proper structure and function of the heart may be impaired by nonfunctional MAS1.
MAS1 (N-15)
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MAS1 (N-15): sc-54682. Western blot analysis of MAS1 expression in A549 whole cell lysate.