epitope mapping at the C-terminus of ADAMTS-1 of human origin
recommended for detection of ADAMTS-1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
ADAMTS-1 Background Information ADAMTS-1, also known as METH-1, C3-C5 and KIAA1346, and the related protein ADAMTS-8, also known as METH-2 and FLJ41712, represent a new family of proteins with metalloprotease, disintegrin and Thrombospondin domains. ADAMTS-1 and ADAMTS-2 are secreted and proteolytically processed proteins that are 51.7% identical but display different, non-overlapping patterns of expression in tissues and cultured celllines. Both ADAMTS proteins have been shown to be more active than Thrombospondin-1 or endostatin in preventing angiogenesis in a cornea pocket model, and both may have application for the inhibition of new blood vessel formation in a range of tumor types. The spacer region and the Thrombospondin type I motifs in the carboxy-terminus of ADAMTS-1 are important for anchoring ADAMTS-1 to the extracellular matrix.
ADAMTS-1 (C-13) Product Citations
See how others have used ADAMTS-1 (C-13): sc-5463 antibody and or ADAMTS-1 (C-13) antibody conjugates.
