epitope mapping within an internal region of AGR2 of human origin
recommended for detection of AGR2 of mouse, rat and human origin by IP, IF and ELISA; also reactive with additional species, including equine, canine and bovine
AGR2 Background Information AGR2 (Anterior Gradient Protein 2), also known as AG2, GOB-4 or HAG-2, is a member of the anterior gradient homolog family. It is the human ortholog of XAG-2, the secreted Xenopus laevis Anterior Gradient protein. In X. laevis, it is involved in cement gland differentiation and neural marker gene expression. AGR2 is a secretory protein encoded by two different AGR2 transcripts. It interacts with LYPD3 and å-dystroglycan (DAG-1). AGR2 is ubiquitously expressed with up-regulated expression in prostate cancer, breast cancer, lung cancer, renal carcinomas and endometrial carcinomas. AGR2 expression is positively correlated with that of the estrogen receptor (ER) and is negatively correlated with that of the epidermal growth factor receptor (EGFR). AGR2 may serve as a potential therapeutic marker for various cancers.
AGR2 (Y-14)
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AGR2 (Y-14): sc-54562. Western blot analysis of AGR2 expression in MCF7 whole cell lysate.
