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SA-1 Antibody (S-16): sc-54466

 |  Datasheet

(Based on data analysis)
  • SA-1 Antibody (S-16) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of SA-1 of human origin
  • recommended for detection of cohesin subunit SA-1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
  • blocking peptide, sc-54466 P
 

See additional SA Antibodies including SA, SA-1 and SA-2.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
SA-1 Antibody (S-16) sc-54466 200 µg/ml $279
SA-1 (S-16) P sc-54466 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SA-1 siRNA (h) sc-62968 10 µM $258
SA-1 siRNA (m) sc-62969 10 µM $258
SA-1 (h)-PR sc-62968-PR 10 µM, 20 µl $23
SA-1 (m)-PR sc-62969-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SA-1 shRNA Plasmid (h) sc-62968-SH 20 µg $520
SA-1 shRNA Plasmid (m) sc-62969-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
SA-1 shRNA (h) Lentiviral Particles sc-62968-V 200 µl $625
SA-1 shRNA (m) Lentiviral Particles sc-62969-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
HuT 78 Whole Cell Lysate sc-2208 500 µg/200 µl $104
HEL 92.1.7 Cell Lysate sc-2270 500 µg/200 µl $104
mouse spleen extract sc-2391 500 µg/200 µl $104
mouse thymus extract sc-2406 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human STAG1 10274 3q22.3 NM_005862 Q8WVM7
 604358
Mouse Stag1 20842 9 E4 Q9D3E6
 N/A
 

The cohesion complex is a multi-protein structure that is required for cohesion of sister chromatids after DNA replication and may be involved in mitotic spindle pole assembly. The complex is composed of a heterodimer between SMC1 and SMC3, two proteins that are linked at their heads by Rad21, and an additional protein called SA-1 (stromal antigen 1). SA-1, also known as STAG1, is a 1258 amino acid component of the cohesion complex that interacts directly with Rad21. Localized to the nucleus, SA-1 associates with chromatin and, upon phosphorylation by Plk, dissociates from chromatin to allow proper chromosome separation during anaphase. SA-1, the human homolog of yeast Scc3p, is expressed in thymus, bone marrow and spleen and is 99% similar to its mouse counterpart.