epitope mapping at the C-terminus of CARM1 of mouse origin
recommended for detection of CARM1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
blocking peptide, sc-5421 P
TransCruz reagent for ChIP application, sc-5421 X, 200 µg/0.1 ml
CARM1 Background Information CARM1 (coactivator-associated arginine methyltransferase 1), also known as protein arginine N-methyltransferase 4 (PRMT4), is a 585 amino acid nuclear and cytoplasmic protein belonging to the protein arginine N-methyltransferase family. As a protein arginine N-methyltransferase, CARM1 is capable of catalyzing the transfer of methyl groups from S-adenosylmethionine to the guanidino group nitrogen atoms of arginine residues in certain proteins involved in mRNA stability, DNA packaging and transcriptional regulation. The methyltransferase activity of CARM1 has been found to be negatively regulated through phosphorylation at a conserved serine residue. CARM1 acts as a positive regulator for multiple transcription factors and functions as a secondary coactivator through its association with p160 coactivators. CARM1 exists as two alternatively spliced isoforms, and is encoded by a gene that maps to human chromosome 19p13.2.
CARM1 (M-16) Product Citations
See how others have used CARM1 (M-16): sc-5421 antibody and or CARM1 (M-16) antibody conjugates.
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CARM1 (M-16)
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CARM1 (M-16): sc-5421. Western blot analysis of CARM1 expression in non-transfected: sc-117752 (A) and mouse CARM1 transfected: sc-119000 (B) 293T whole cell lysates.
