 |
- goat polyclonal IgG, 200µg/ml
- epitope mapping near the C-terminus of HBXIP of human origin
- recommended for detection of HBX-interacting protein of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-54080 P
|
|
| |
Ordering Information
Recommended Support Products:
(click button of application of choice)
| |
| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
HBXIP |
10542 |
1p13.3 |
NM_006402 |
O43504
|
608521 |
| Mouse |
Hbxip |
68576 |
3 F2.3 |
|
Q9D1L9
|
N/A |
| |
HBXIP Background Information
HBXIP (hepatitis B virus X-interacting protein), also known as HBV X-interacting protein or HBX-interacting protein, was originally identified by its ability to form a complex with the C-terminus of hepatitis B virus X (HBX) protein. HBXIP negatively regulates the activity of HBX and alters the replicative life cycle of the virus. HBXIP is an evolutionarily conserved protein. It contains a leucine zipper motif and two consensus phosphorylation sites. HBXIP also forms complexes with survivin (an overexpressed protein in most human cancers) and is necessary for allowing survivin to bind and inhibit the activation of pro-caspase-9, suggesting that HBXIP acts as an anti-apoptotic cofactor of survivin. In addition, HBXIP is involved in bipolar spindle formation and regulates centrosome dynamics and cytokinesis in cells, possibly through an interaction with Dynein light chain. The overexpression of HBXIP promotes proliferation in a variety of cells lines. |
|
|
HBXIP (C-16)
Click on image to enlarge
|
|
HBXIP (C-16): sc-54080. Western blot analysis of HBXIP expression in rat spleen (A) and mouse heart (B) tissue extracts and MCF7 (C), HeLa (D), Jurkat (E) and NIH/3T3 (F) whole cell lysates.
|
|
Download
|
|
