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GM2/GD2 Synthase Antibody (P-20): sc-54073

 |  Datasheet

(Based on data analysis)

  • GM2/GD2 Synthase Antibody (P-20) is a goat polyclonal IgG provided at 200 µg/ml
  • epitope mapping within an internal region of GM2 of human origin
  • recommended for detection of GM2/GD2 Synthase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and bovine
  • blocking peptide, sc-54073 P
 

See additional Ganglioside Antibodies including Ganglioside, Ganglioside sialidase, Ganglioside GD2, Ganglioside GD3 and GM2/GD2 Synthase.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   IF   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAdd 
GM2/GD2 Synthase Antibody (P-20) sc-54073 200 µg/ml $279
GM2/GD2 synthase (P-20) P sc-54073 P
(peptide)
 100 µg/0.5 ml $61
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM2/GD2 synthase siRNA (h) sc-105401 10 µM $258
GM2/GD2 synthase siRNA (m) sc-77390 10 µM $258
GM2/GD2 synthase (h)-PR sc-105401-PR 10 µM, 20 µl $23
GM2/GD2 synthase (m)-PR sc-77390-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM2/GD2 synthase shRNA Plasmid (h) sc-105401-SH 20 µg $520
GM2/GD2 synthase shRNA Plasmid (m) sc-77390-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
GM2/GD2 synthase shRNA (h) Lentiviral Particles sc-105401-V 200 µl $625
GM2/GD2 synthase shRNA (m) Lentiviral Particles sc-77390-V 200 µl $625
 WB Positive Control Cell Lysates (click product name for more information)
Product NameCatalog #UnitPriceQtyAdd 
mouse brain extract sc-2253 500 µg/200 µl $104
rat brain extract sc-2392 500 µg/200 µl $104
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human B4GALNT1 2583 12q14.1 NM_001478 Q00973
 601873
Mouse B4galnt1 14421 10 D3 Q09200
 N/A
 

GM2/GD2 synthase is a 533 amino acid protein encoded by the human gene B4GALNT1. The GM2 and GD2 gangliosides are sialic acid-containing glyco-sphingolipids that play a role in signal transduction and cell-cell recognition. GM2/GD2 synthase is expressed abundantly in normal brain tissue of vertebrates. It contains a single 18 amino acid hydrophobic segment near the amino-terminus flanked by basic residues. GM2/GD2 synthase primarily controls the balance between expression of simple and complex gangliosides at the cell surface. The ganglioside GD2 is expressed using GM2/GD2 synthase in almost all neuroblastomas (NBs) as well as other neuroectoderm-derived tumor cells, such as malignant melanoma, adult T cell leukemia and some colon and gastric cancers. GM2/GD2 synthase is a useful marker for NBs and may aid in evaluating adjuvant treatment efficacy in neuroblastoma with prognostic potential.
GM2/GD2 Synthase Antibody (P-20) Data
Click on image to enlarge
sc-54073
GM2/GD2 Synthase (P-20): sc-54073. Western blot analysis of GM2/GD2 Synthase expression in HeLa whole cell lysate.
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