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- mouse monoclonal IgG2a; 200 µg/ml
- raised against amino acids 224-230, mapping within a central region of Cdc2 of human origin
- recommended for detection of Cdc2 p34 of multiple species (including, murine, human and Xenopus) by WB, IP, KA, IF and IHC(P)
- agarose conjugate for IP studies, Cdc2 p34 (17) AC: sc-54 AC, 500 µg/0.25 ml agarose
- fluorescein (Cdc2 p34 (17) FITC: sc-54 FITC) and rhodamine (Cdc2 p34 (17) TRITC: sc-54 TRITC) conjugates for immunofluorescence, 200 µg/ml
- HRP conjugate, Cdc2 p34 (17) HRP: sc-54 HRP, 200 µg/ml
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Cdc2 p34 Background Information
In vertebrates, as in yeast, multiple cyclins have been identified, including a total of eight such regulatory proteins in mammals. In contrast to the situation in yeast, the Cdc2 p34 kinase is not the only catalytic subunit identified in vertebrates that can interact with cyclins. While Cdc2 p34 is essential for the G2 to M transition in vertebrate cells, a second Cdc2-related kinase has also been implicated in cell cycle control. This protein, designated cyclin-dependent kinase 2 (Cdk2) p33, also binds to cyclins and its kinase activity is temporally regulated during the cell cycle. Several additional Cdc2 p34-related cyclin dependent kinases have been identified. These include Cdk3-Cdk8, PCTAIRE-1-3 and KKIALRE.
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See how others have used Cdc2 p34 (17): sc-54 antibody and or Cdc2 p34 (17) antibody conjugates.
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Cdc2 p34 (17)
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Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in A-431 nuclear extract.
Cdc2 p34 (17): sc-54. Immunofluorescence staining of methanol-fixed HeLa cells showing specific staining of nuclei and centrosomes (A). Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue showing nuclear staining of selected cells (B).
Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in non-transfected 293: sc-110760 (A), human Cdc2 p34 transfected 293: sc-128282 (B) and HeLa (C) whole cell lysates. Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in non-transfected 293T: sc-117752 (A), mouse Cdc2 p34 transfected 293T: sc-119124 (B) and K-562 (C) whole cell lysates. Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in HeLa whole cell lysate.
Cdc2 p34 (17): sc-54. Western blot analysis of Cdc2 p34 expression in untreated (A) and Licochalcone-A, Synthetic ( sc-319884) treated (B) PC-3 whole cell lysates. Note down regulation of Cdc2 p34 expression in lane B. |
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