CKR-9 Background Information
C-C or ∫ chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-7, CKR-8, CKR-9, CKR-10 and the Duffy blood group antigen.. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins, whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. CKR-9, also designated GPR-9-6, is a receptor for the thymus expressed chemokine TECK. CKR-9 and TECK are thought to have a specialized role in the immune response because both are highly expressed by T lymphocytes in the small intestine, while T lymphocytes in several other tissues are CKR-9/TECK negative.
