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Mucin 4 Antibody (8G7): sc-53945

 |  Datasheet

(Based on data analysis)

  • Mucin 4 Antibody (8G7) is a mouse monoclonal IgG1 provided at 200 µg/ml
  • raised against a synthetic peptide directed against the Mucin 4 tandem repeats of human origin
  • recommended for detection of Mucin 4 of human origin by WB, IF and IHC(P)
  • See 3 citations for Mucin 4 Antibody (8G7)
 

See additional Mucin Antibodies including Mucin, Epithelial sialomucin, Mucin 1, Mucin 10, Mucin 19, Mucin 20, Mucin 21, Mucin 22, Mucin 2, Mucin 3, Mucin 3A, Mucin 3B, Mucin 4, Mucin 5AC, Mucin 5B, Mucin 6, Mucin 7, Mucin 8, Mucin 11, Mucin 12, Mucin 13, Mucin 15, Mucin 16 and Mucin 17.

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WB   IF   IHC(P)   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
Mucin 4 Antibody (8G7) sc-53945 200 µg/ml $295
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Mucin 4 siRNA (h) sc-43163 10 µM $258
Mucin 4 siRNA (h2) sc-61703 10 µM $258
Mucin 4 (h)-PR sc-43163-PR 10 µM, 20 µl $23
Mucin 4 (h2)-PR sc-61703-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Mucin 4 shRNA Plasmid (h) sc-43163-SH 20 µg $520
Mucin 4 shRNA Plasmid (h2) sc-61703-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
Mucin 4 shRNA (h) Lentiviral Particles sc-43163-V 200 µl $625
Mucin 4 shRNA (h2) Lentiviral Particles sc-61703-V 200 µl $625
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human MUC4 4585 3q29 NM_004532, NM_018406, NM_138297 Q99102
158372
 


Mucins are a group of high molecular weight glycoproteins consisting of a mucin core protein and O-linked carbohydrates. Mucin 4, a membrane-bound mucin, is the human homolog of the rat sialomucin complex (SMC). Mucin 4 protein consists of Mucin 4α, a large amino mucin type subunit, and Mucin 4β, a transmembrane subunit containing three EGF-like domains. The Mucin 4 gene is the predominant mucin gene expressed in the normal urothelium and is also expressed in several normal tissues such as trachea, lung and testis. Dysregulation of Mucin 4 results in high levels of expression in pancreatic tumors and tumor cell lines. Induction of Mucin 4 in pancreatic carcinoma by all-trans-retinoic acid is mediated through the retinoic acid receptor-å signaling pathway. TGFβ2 serves as an interim mediator of this regulated expression. Alternative splicing in the 3'-end of the Mucin 4 gene generates at least 12 splice variants, which are characterized as two distinct types, a secreted type and a membrane-associated type. Mucin 4 protein acts as a heterodimeric bifunctional cell-surface glycoprotein and forms thick mucous effusion in the diseased middle ear.

Mucin 4 Antibody (8G7) Product Citations
See how others have used Mucin 4 Antibody (8G7) and or Mucin 4 Antibody (8G7) conjugates.


3 total citations
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Mucin 4 Antibody (8G7) Data
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Mucin 4 (8G7): sc-53945. Western blot analysis of Mucin 4 expression in Panc-1 (A), CD-18/HPAF (B) and Colo357 (C) cells showing glycosylation. Kindly provided by Dr. Surinder Batra, University of Nebraska Medical Center.
Mucin 4 (8G7): sc-53945. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing membrane and cytoplasmic staining of glandular cells.
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