Acrp30 Background Information Acrp30 (adipocyte complement-related protein or AdipoQ) is a secretory protein made exclusively in adipocytes with mRNA induced over 100-fold during adipocyte differentiation. Post-transcriptional modification of Acrp30 yields several oligomeric forms of varying molecular weight, including a monomer, a dimer, a trimer, a hexamer and a polymer. Acrp30 is an abundant serum protein, secreted exclusively from fat cells, and is implicated in energy homeostasis and obesity. Due to the dysregulation of Acrp30 in cases of obesity in humans and mice and the strong structural similarity to TNFå, Acrp30 is a suspected regulator of whole body energy homeostasis. In addition, regulated exocytosis of Acrp30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated Acrp30 secretion is blocked by pharmacologic inhibitors of this enzyme.
Acrp30 (1G12)
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Acrp30 (1G12): sc-53910. Western blot analysis of full-length recombinant human Acrp30 (A) and mouse liver extract (B). Arrows indicate the oligomer and monomer of mAcrp30 protein in mouse liver.
