MAGE-C1 Background Information The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors. Based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens and are expressed in tumors of different histologic types, but not in normal tissues, with the exception of testis and placenta. Although a large number of MAGE genes have now been identified and extensively studied in tumors of various origin, their function in normal cells remains unknown. Also referred to as CT7, MAGE-C1 is a member of the MAGE family that is expressed in multiple myeloma and that correlates with plasma-cell proliferation.
MAGE-C1 (CT7-33)
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MAGE-C1 (CT7-33): sc-53868. Western blot analysis of MAGE-C1 expression in human testis tissue extract (A) and Hs 294T (B), SK-MEL-28 (C), U-87 MG (D) and JEG-3 (E) whole cell lysates and U266 nuclear extract (F).
MAGE-C1 (CT7-33): sc-53868. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in seminiferus ducts (low and high magnification). Kindly provided by The Swedish Human Protein Atlas (HPA) program.
