Welcome to Santa Cruz Biotechnology!

PARC Antibody (PO69): sc-53748

 |  Datasheet

(Based on data analysis)

  • PARC Antibody (PO69) is a mouse monoclonal IgG1 provided at 50µg/0.5 ml
  • raised against PARC of human origin
  • recommended for detection of PARC of mouse and human origin by WB and IP

See additional PARC Antibodies.

Ordering InformationGene Info
Recommended Support Products:
(click button of application of choice)
WB   IP   siRNA  
Set Currency

 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PARC Antibody (PO69) sc-53748 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC siRNA (h) sc-44715 10 µM $258
PARC siRNA (m) sc-44716 10 µM $258
PARC (h)-PR sc-44715-PR 10 µM, 20 µl $23
PARC (m)-PR sc-44716-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC shRNA Plasmid (h) sc-44715-SH 20 µg $520
PARC shRNA Plasmid (m) sc-44716-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC shRNA (h) Lentiviral Particles sc-44715-V 200 µl $625
PARC shRNA (m) Lentiviral Particles sc-44716-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PARC 23113 6p21.1 NM_015089 Q8IWT3
Mouse Parc 78309 17 C Q80TT8

The p53 tumor suppressor gene is altered in over 50% of human cancers. The p53 binding proteins 53BP1 and 53BP2 (Bbp) are tumor suppressors that bind to the site-specific central DNA-binding domain of wild type p53 in a conformation-dependent manner. Severe DNA damage can cause phosphorylation of p53 at position serine-46. This event triggers expression of p53AIP1 (apoptosis inducing protein), which contributes to subsequent events leading to programmed cell death. The protein PARC (p53 associated Parkin-like cytoplasmic protein) acts as a cytoplasmic anchor for p53 in unstressed cells, thereby regulating the localization and subsequent function of p53. The C-terminus of the PARC protein contains a RING-IBR-RING domain, which suggests it retains ubiquitin ligase activity, but PARC fails to promote degradation of p53. The gene encoding human PARC maps to chromosome 6p21.1.

PARC Antibody (PO69) Data
Click on image to enlarge
PARC (PO69): sc-53748. Western blot analysis of PARC expression in 293T (A) and HeLa (B) whole cell lysates.