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PARC Antibody (PO69): sc-53748

 |  Datasheet

(Based on data analysis)

  • PARC Antibody (PO69) is a mouse monoclonal IgG1 provided at 50µg/0.5 ml
  • raised against PARC of human origin
  • recommended for detection of PARC of mouse and human origin by WB and IP
 

See additional PARC Antibodies.

Ordering InformationGene Info
Recommended Support Products:
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WB   IP   siRNA  
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 Ordering Information
Product NameCatalog #UnitPriceQtyAddFavorites
PARC Antibody (PO69) sc-53748 50 µg/0.5 ml $279
 siRNA Gene Silencers (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC siRNA (h) sc-44715 10 µM $258
PARC siRNA (m) sc-44716 10 µM $258
PARC (h)-PR sc-44715-PR 10 µM, 20 µl $23
PARC (m)-PR sc-44716-PR 10 µM, 20 µl $23
 shRNA Plasmids (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC shRNA Plasmid (h) sc-44715-SH 20 µg $520
PARC shRNA Plasmid (m) sc-44716-SH 20 µg $520
 shRNA Lentiviral Particles (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
PARC shRNA (h) Lentiviral Particles sc-44715-V 200 µl $625
PARC shRNA (m) Lentiviral Particles sc-44716-V 200 µl $625
 WB Positive Control Cell Lysate (click product name for more information)
Product NameCatalog #UnitPriceQtyAddFavorites
HeLa Whole Cell Lysate sc-2200 500 µg/200 µl $104
 
Species Gene Name Gene ID Chromosome Location Isoform (mRNA) Accession # Protein Accession # OMIM™ Number
Human PARC 23113 6p21.1 NM_015089 Q8IWT3
607489
Mouse Parc 78309 17 C Q80TT8
N/A
 


The p53 tumor suppressor gene is altered in over 50% of human cancers. The p53 binding proteins 53BP1 and 53BP2 (Bbp) are tumor suppressors that bind to the site-specific central DNA-binding domain of wild type p53 in a conformation-dependent manner. Severe DNA damage can cause phosphorylation of p53 at position serine-46. This event triggers expression of p53AIP1 (apoptosis inducing protein), which contributes to subsequent events leading to programmed cell death. The protein PARC (p53 associated Parkin-like cytoplasmic protein) acts as a cytoplasmic anchor for p53 in unstressed cells, thereby regulating the localization and subsequent function of p53. The C-terminus of the PARC protein contains a RING-IBR-RING domain, which suggests it retains ubiquitin ligase activity, but PARC fails to promote degradation of p53. The gene encoding human PARC maps to chromosome 6p21.1.

PARC Antibody (PO69) Data
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PARC (PO69): sc-53748. Western blot analysis of PARC expression in 293T (A) and HeLa (B) whole cell lysates.
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