CYP4F11 Background Information The cytochrome P450 proteins (CYPs) are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP4F11 is an isoform of the cytochrome P450 4F protein and is expressed mainly in human liver, followed by kidney, heart and skeletal muscle. CYP4F11 contains 524 amino acid residues that share 80.0, 82.3 and 79.2% identity to CYP4F2, CYP4F3 and CYP4F8 amino acid sequences, respectively. CYP4F11 has catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs, and is able to metabolize large molecules such as erythromycin.
CYP4F11 (F21 P6 F5)
Click on image to enlarge
CYP4F11 (F21 P6 F5): sc-53619. Western blot analysis of CYP4F11 expression in non-transfected: sc-117752 (A) and human CYP4F11 transfected: sc-112784 (B) 293T whole cell lysates.
CYP4F11 (F21 P6 F5): sc-53619. Western blot analysis of CYP4F11 expression in non-transfected: sc-117752 (A) and human CYP4F11 transfected: sc-175635 (B) 293T whole cell lysates.
