goat polyclonal IgG, 200 µg/ml epitope mapping near the C-terminus of HNF-3γ of human origin recommended for detection of HNF-3γ of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine blocking peptide, sc-5360 P TransCruz reagent for Gel Supershift and ChIP applications, sc-5360 X, 200 µg/0.1 ml
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Species
Gene Name
Gene ID
Chromosome Location
Isoform (mRNA) Accession #
Protein Accession #
OMIM™ Number
Human
FOXA3
3171
19q13.32
NM_004497
P55318
602295
Mouse
Foxa3
15377
7 A3
P35584
N/A
HNF-3γ Background Information HNF-1 (å and ∫), HNF-3 (å, ∫ and ©), HNF-4 (å and ©), and HNF-6 compose, in part, a homeoprotein family designated the Hepatocyte Nuclear Factor family. The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus. HNF-3å, HNF-3∫ and HNF-3© regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3å and HNF-3∫ have also been shown to be involved in gastrulation events such as body axis formation. HNF-4å and HNF-4© have been shown to be important for early embryo development. HNF-4å is expressed in liver, kidney, pancreas, small intestine, testis and colon; HNF-4© is expressed in each of these tissues except liver. HNF-6 has been shown to bind to the promoter of HNF-3∫, which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and å-1 antitrypsin.
HNF-3γ (K-15) Product Citations
See how others have used HNF-3γ (K-15): sc-5360 antibody and or HNF-3γ (K-15) antibody conjugates.
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