raised against mesentereic lymphocytes and TK-1 cells of mouse origin
recommended for detection of Integrin β7 of mouse origin by WB, IP and FCM
also provided azide-free for inducing aggregation via an α4β7 pathway, sc-53545 L, 200 µg/0.1 mlfluorescein (sc-53545 FITC) and phycoerythrin (sc-53545 PE) conjugates for FCM, 100 tests
Integrin β7 Background Information Integrins are heterodimers composed of noncovalently associated transmembrane å and ∫ subunits. The 16 å and 8 ∫ subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
