pan-Cytokeratin Background Information Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation which is directly applicable to the characterization of malignant tumors. For example, cytokeratins 10 and 13 are expressed highly in a subset of squamous cell carcinomas while cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas.
pan-Cytokeratin (HEP 111)
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pan-Cytokeratin (HEP 111): sc-53401. Western blot analysis of pan-Cytokeratin expression in Hep G2 (A) and Caco-2 (B) whole cell lysates.
pan-Cytokeratin (HEP 111): sc-53401. Western blot analysis of Cytokeratin 20 expression in non-transfected: sc-117752 (A) and human Cytokeratin 20 transfected: sc-174535 (B) 293T whole cell lysates.
