FOXJ1 Background Information Forkhead-box J1 (FOXJ1) is a 421-amino acid transcription factor that suppresses T cell activity and thus spontaneous autoimmunity, through the repression of NF˚B activity. FOXJ1 also inhibits the humoral immune response in B cells; FOXJ1 deficiency in B cells results in spontaneous and accentuated germinal center formation, implicated in the development of pathogenic autoantibodies and accentuated responses to immunizations. Abnormal expression of FOXJ1 may be associated with autoimmune diseases and/or other inflammatory diseases. FOXJ1 is also required for cilia formation and left-right axis determination because it increases calpastatin expression, a protein necessary for the ability of basal bodies to anchor to the apical cytoskeleton. FOXJ1 expression may function as an early marker of epithelial cell differentiation, recovery, and function.
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FOXJ1 (3-19)
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FOXJ1 (3-19): sc-53139. Western blot analysis of FOXJ1 expression in H69AR (A) and A549 (B) whole cell lysates.
FOXJ1 (3-19): sc-53139. Western blot analysis of FOXJ1 expression in non-transfected: sc-117752 (A) and human FOXJ1 transfected: sc-115631 (B) 293T whole cell lysates.
FOXJ1 (3-19): sc-53139. Western blot analysis of FOXJ1 expression in A549 whole cell lysate (A) and rat lung (B) and mouse lung (C) tissue extracts.
