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TTF-1 (8G7G3/1) Antibody: sc-53136 |
| Datasheet |
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- mouse monoclonal IgG1, 200µg/ml
- raised against full length recombinant TTF-1 of rat origin
- recommended for detection of TTF-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
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Ordering Information
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| Species |
Gene Name |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| Human |
NKX2-1 |
7080 |
14q13.3 |
NM_003317 |
P43699
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610978 |
| Mouse |
Nkx2-1 |
21869 |
12 C1 |
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P50220
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N/A |
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TTF-1 Background Information TTF-1 (thyroid transcription factor-1, BCH, BHC, NK-2, Nkx2.1, Nkx2A, TEBP, TTF1) is a member of the Nkx2 family of homeodomain-containing transcription factors and regulates the transcriptional activity of thyroid-specific genes. TTF-1 influences organogenisis and the maintenance of the differentiated phenotypes of various tissues including thyroid, lung and brain. TTF-1, which is present in the epithelium of the lung, regulates transcription of the surfactant proteins (SP) A, B and C and is essential for lung morphogenesis. In the thyroid, TTF-1 elevates the expression of thyroid specific markers, thyroglobulin, thyroperoxidase and thyrotropin receptors. TTF-1 interacts with SRC-1 and CBP in vitro. |
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TTF-1 (8G7G3/1)
Click on image to enlarge
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TTF-1 (8G7G3/1): sc-53136. Western blot analysis of TTF-1 expression in TT whole cell lysate.
TTF-1 (8G7G3/1): sc-53136. Western blot analysis of TTF-1 expression in non-transfected: sc-117752 (A) and human TTF-1 transfected: sc-159187 (B) 293T whole cell lysates.
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